TargetMol

AV-412

Product Code:
 
TAR-T10419
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10419-1mg1mg£100.00
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TAR-T10419-2mg2mg£113.00
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TAR-T10419-5mg5mg£140.00
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TAR-T10419-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T10419-10mg10mg£189.00
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TAR-T10419-25mg25mg£285.00
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TAR-T10419-50mg50mg£430.00
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TAR-T10419-100mg100mg£589.00
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Further Information

Bioactivity:
AV-412 is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).
CAS:
451493-31-5
Formula:
C41H44ClFN6O7S2
Molecular Weight:
851.41
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9985
SMILES:
Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Target:
EGFR

References

1. Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84.