TargetMol

LY2365109 hydrochloride

Product Code:
 
TAR-T11908
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11908-1mg1mg£98.00
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TAR-T11908-2mg2mg£109.00
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TAR-T11908-5mg5mg£135.00
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TAR-T11908-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T11908-10mg10mg£173.00
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TAR-T11908-25mg25mg£269.00
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TAR-T11908-50mg50mg£369.00
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TAR-T11908-100mg100mg£503.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
CAS:
1779796-27-8
Formula:
C22H28ClNO5
Molecular Weight:
421.91
Pathway:
Neuroscience
Purity:
0.9947
SMILES:
O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
Target:
GlyT

References

1. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. 2. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.