TargetMol

MMAF-OMe

Product Code:
 
TAR-T12081
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12081-5mg5mg£116.00
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TAR-T12081-10mg10mg£140.00
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TAR-T12081-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T12081-25mg25mg£176.00
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This product comes from: United States.
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Further Information

Bioactivity:
MMAF-OMe is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.
CAS:
863971-12-4
Formula:
C40H67N5O8
Molecular Weight:
746.003
Purity:
0.9934
SMILES:
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C

References

1. Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300