TargetMol

BTRX-335140

Product Code:
 
TAR-T14835
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14835-1mg1mg£173.00
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TAR-T14835-2mg2mg£222.00
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TAR-T14835-5mg5mg£325.00
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TAR-T14835-1mL1 mL * 10 mM (in DMSO)£342.00
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TAR-T14835-10mg10mg£497.00
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TAR-T14835-25mg25mg£838.00
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Quantity:
TAR-T14835-50mg50mg£1,476.00
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Quantity:
TAR-T14835-100mg100mg£2,046.00
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Quantity:
TAR-T14835-200mg200mg£2,745.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BTRX-335140 is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) . BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats.
CAS:
2244614-14-8
Formula:
C25H32FN5O2
Molecular Weight:
453.562
Pathway:
Endocrinology/Hormones; Neuroscience; GPCR/G Protein
Purity:
0.9845
SMILES:
CCc1cc(F)c2nc(N3CCC(CC3)NC3CCOCC3)c(-c3nc(C)no3)c(C)c2c1
Target:
Opioid Receptor

References

1. Guerrero M, et al. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). J Med Chem. 2019 Feb 28;62(4):1761-1780.