TargetMol

LP-935509

Product Code:
 
TAR-T15781
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15781-1mg1mg£97.00
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TAR-T15781-2mg2mg£108.00
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TAR-T15781-5mg5mg£132.00
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TAR-T15781-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T15781-10mg10mg£177.00
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TAR-T15781-25mg25mg£283.00
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TAR-T15781-50mg50mg£466.00
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TAR-T15781-100mg100mg£648.00
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Further Information

Bioactivity:
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM).
CAS:
1454555-29-3
Formula:
C20H24N6O3
Molecular Weight:
396.451
Pathway:
Neuroscience; Cell Cycle/Checkpoint; Metabolism
Purity:
0.9964
SMILES:
COc1ncccc1-c1cnn2ccc(nc12)N1CCN(CC1)C(=O)OC(C)C
Target:
Serine/threonin kinase; AAK1 (AP2 associated kinase 1)

References

1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.