TargetMol

Marizomib

Product Code:
 
TAR-T16012
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T16012-1mg1mg£456.00
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TAR-T16012-5mg5mg£858.00
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TAR-T16012-10mg10mg£1,131.00
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Further Information

Bioactivity:
Marizomib suppresses the CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively). Marizomib is a second-generation, irreversible, brain-penetrant inhibitor of pan-proteasome.
CAS:
437742-34-2
Formula:
C15H20ClNO4
Molecular Weight:
313.78
Pathway:
Ubiquitination|Proteases/Proteasome
Purity:
0.98
SMILES:
C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1
Target:
Proteasome

References

1. Di K, et al. Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brainbarrier. Neuro Oncol. 2016 Jun;18(6):840-8. 2. Kale AJ, et al. Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem. 2012 Dec 13;55(23):10317-27. 3. Singh AV, et al. Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. Br J Haematol. 2010 May;149(4):550-9.