TargetMol

Quiflapon

Product Code:
 
TAR-T16087
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16087-1mg1mg£113.00
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TAR-T16087-2mg2mg£132.00
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TAR-T16087-5mg5mg£152.00
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TAR-T16087-10mg10mg£189.00
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TAR-T16087-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T16087-25mg25mg£341.00
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TAR-T16087-50mg50mg£464.00
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TAR-T16087-100mg100mg£655.00
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Further Information

Bioactivity:
Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively).
CAS:
136668-42-3
Formula:
C34H35ClN2O3S
Molecular Weight:
587.18
Pathway:
Apoptosis; Immunology/Inflammation
Purity:
0.9888
SMILES:
CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12
Target:
Apoptosis; FLAP

References

1. Brideau C, et al. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. 2. Park MS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Lung. 2011 Feb;189(1):43-50.