TargetMol

Filorexant

Product Code:
 
TAR-T16096
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16096-1mg1mg£119.00
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TAR-T16096-2mg2mg£141.00
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TAR-T16096-5mg5mg£189.00
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TAR-T16096-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T16096-10mg10mg£269.00
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TAR-T16096-25mg25mg£414.00
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TAR-T16096-50mg50mg£579.00
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TAR-T16096-100mg100mg£780.00
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Further Information

Bioactivity:
Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
CAS:
1088991-73-4
Formula:
C24H25FN4O2
Molecular Weight:
420.488
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9933
SMILES:
C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
Target:
OX Receptor

References

1. Winrow CJ, et al. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62(2):978-87. 2. Coleman PJ, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7(3):415-24, 337.