TargetMol

MLi-2

Product Code:
 
TAR-T16115
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16115-1mg1mg£119.00
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TAR-T16115-2mg2mg£141.00
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TAR-T16115-5mg5mg£179.00
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TAR-T16115-1mL1 mL * 10 mM (in DMSO)£187.00
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TAR-T16115-10mg10mg£237.00
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TAR-T16115-25mg25mg£438.00
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TAR-T16115-50mg50mg£627.00
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TAR-T16115-100mg100mg£862.00
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Further Information

Bioactivity:
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
CAS:
1627091-47-7
Formula:
C21H25N5O2
Molecular Weight:
379.464
Pathway:
Autophagy
Purity:
0.9933
SMILES:
[H][C@]1(C)CN(C[C@@]([H])(C)O1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Target:
LRRK2

References

1. Fell MJ, et al. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409.