TargetMol

MMV390048

Product Code:
 
TAR-T16125
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16125-1mg1mg£115.00
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TAR-T16125-2mg2mg£136.00
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TAR-T16125-5mg5mg£177.00
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TAR-T16125-1mL1 mL * 10 mM (in DMSO)£187.00
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TAR-T16125-10mg10mg£252.00
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TAR-T16125-25mg25mg£436.00
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TAR-T16125-50mg50mg£614.00
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TAR-T16125-100mg100mg£844.00
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This product comes from: United States.
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Further Information

Bioactivity:
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns.
CAS:
1314883-11-8
Formula:
C18H14F3N3O2S
Molecular Weight:
393.38
Pathway:
Microbiology/Virology; PI3K/Akt/mTOR signaling
Purity:
0.9828
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(c1)-c1ccc(nc1)C(F)(F)F
Target:
Parasite; PI4K

References

1. Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.