TargetMol

Norverapamil hydrochloride

Product Code:
 
TAR-T16339
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16339-1mg1mg£113.00
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TAR-T16339-2mg2mg£132.00
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TAR-T16339-5mg5mg£164.00
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TAR-T16339-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-T16339-10mg10mg£229.00
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TAR-T16339-25mg25mg£433.00
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TAR-T16339-50mg50mg£603.00
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TAR-T16339-100mg100mg£823.00
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This product comes from: United States.
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Further Information

Bioactivity:
Norverapamil hydrochloride ((?)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
CAS:
67812-42-4
Formula:
C26H37ClN2O4
Molecular Weight:
477.04
Pathway:
Metabolism; Neuroscience; Membrane transporter/Ion channel
Purity:
0.9963
SMILES:
Cl.COc1ccc(CCNCCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Target:
Calcium Channel; P-gp; Drug Metabolite

References

1. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. 2. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. 3. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302. 4. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8.