TargetMol

Mardepodect

Product Code:
 
TAR-T16499
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16499-1mg1mg£99.00
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TAR-T16499-2mg2mg£111.00
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TAR-T16499-5mg5mg£138.00
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TAR-T16499-1mL1 mL * 10 mM (in DMSO)£145.00
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TAR-T16499-10mg10mg£193.00
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TAR-T16499-25mg25mg£278.00
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TAR-T16499-50mg50mg£380.00
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TAR-T16499-100mg100mg£533.00
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Further Information

Bioactivity:
Mardepodect is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Mardepodect can cross the blood-brain barrier.
CAS:
898562-94-2
Formula:
C25H20N4O
Molecular Weight:
392.45
Pathway:
Metabolism
Purity:
0.9981
SMILES:
CN(N=C1C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C=C1C5=CC=NC=C5
Target:
PDE

References

1. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196. 2. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590.