TargetMol

Momelotinib

Product Code:
 
TAR-T1849
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1849-1mg1mg£96.00
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TAR-T1849-2mg2mg£107.00
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TAR-T1849-5mg5mg£130.00
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TAR-T1849-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T1849-10mg10mg£148.00
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TAR-T1849-25mg25mg£206.00
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TAR-T1849-50mg50mg£289.00
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TAR-T1849-100mg100mg£455.00
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TAR-T1849-200mg200mg£598.00
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Further Information

Bioactivity:
Momelotinib is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
CAS:
1056634-68-4
Formula:
C23H22N6O2
Molecular Weight:
414.469
Pathway:
Apoptosis; Autophagy; JAK/STAT signaling; Stem Cells; Chromatin/Epigenetic; Angiogenesis
Purity:
0.9956
SMILES:
O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Target:
Apoptosis; JAK; Autophagy

References

1. Pardanani A, et al. Leukemia, 2009, 23(8), 1441-1445. 2. Monaghan KA, et al. Leukemia, 2011, 25(12), 1891-1899. 3. Tyner JW, et al. Blood, 2010, 115(25), 5232-5240. 4. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond?Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11. 5. Li M, Yu H. Identification of WP1066, an inhibitor of JAK2 and STAT3, as a Kv1. 3 potassium channel blocker[J].?. British Journal of Pharmacology. 2021