TargetMol

DUPA

Product Code:
 
TAR-T19301
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19301-2mg2mg£100.00
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TAR-T19301-5mg5mg£118.00
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TAR-T19301-10mg10mg£148.00
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TAR-T19301-25mg25mg£212.00
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TAR-T19301-50mg50mg£309.00
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TAR-T19301-100mg100mg£436.00
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TAR-T19301-200mg200mg£598.00
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Quantity:
TAR-T19301-500mg500mg£863.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
CAS:
302941-52-2
Formula:
C11H16N2O9
Molecular Weight:
320.254
Pathway:
Others|PROTAC
Purity:
0.98
SMILES:
[H][C@@](CCC(O)=O)(NC(=O)N[C@@]([H])(CCC(O)=O)C(O)=O)C(O)=O
Target:
Ligands for Target Protein for PROTAC|Others

References

1. Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80. 2. Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.