TargetMol

PXS-4728A

Product Code:
 
TAR-T26795
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26795-1mg1mg£106.00
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TAR-T26795-2mg2mg£120.00
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TAR-T26795-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T26795-5mg5mg£148.00
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TAR-T26795-10mg10mg£201.00
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TAR-T26795-25mg25mg£349.00
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TAR-T26795-50mg50mg£516.00
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Further Information

Bioactivity:
BI-1467335 is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO) that helps improve chronic obstructive pulmonary disease in mice[2].
CAS:
1478364-68-9
Formula:
C15H22ClFN2O2
Molecular Weight:
316.8
Pathway:
Neuroscience
Purity:
0.9861
SMILES:
Cl.CC(C)(C)NC(=O)c1ccc(OCC(CN)=CF)cc1
Target:
Monoamine Oxidase

References

1. Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015 Mar 20;16:42. 2. Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. Br J Pharmacol. 2016 Nov;173(22):3161-3175. 3. Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E. Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. Kidney Int. 2016 Feb;89(2):374-85.