TargetMol

Ddr1-In-1

Product Code:
 
TAR-T3337
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3337-1mg1mg£98.00
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TAR-T3337-2mg2mg£109.00
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TAR-T3337-5mg5mg£132.00
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TAR-T3337-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T3337-10mg10mg£164.00
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TAR-T3337-25mg25mg£215.00
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TAR-T3337-50mg50mg£302.00
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TAR-T3337-100mg100mg£432.00
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This product comes from: United States.
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Further Information

Bioactivity:
DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.
CAS:
1449685-96-4
Formula:
C30H31F3N4O3
Molecular Weight:
552.598
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9984
SMILES:
CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Oc3ccc4NC(=O)Cc4c3)c2)CC1
Target:
Discoidin Domain Receptor (DDR)

References

Liu G, Jin X, Wang H, et al.Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer.Experimental Cell Research.2022: 113453. Kim HG, et al. ACS Chem Biol. 2013, 8(10), 2145-2150. Wang J, Xie S, Li N, et al. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. Bioactive Materials. 2022