TargetMol

FIPI

Product Code:
 
TAR-T3580
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3580-1mg1mg£96.00
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TAR-T3580-2mg2mg£107.00
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TAR-T3580-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T3580-5mg5mg£128.00
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TAR-T3580-10mg10mg£160.00
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TAR-T3580-25mg25mg£251.00
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TAR-T3580-50mg50mg£396.00
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TAR-T3580-100mg100mg£544.00
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TAR-T3580-500mg500mg£1,099.00
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Further Information

Bioactivity:
FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.
CAS:
939055-18-2
Formula:
C23H24FN5O2
Molecular Weight:
421.476
Pathway:
Autophagy; Metabolism
Purity:
0.9908
SMILES:
Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Target:
Phospholipase; Autophagy

References

Secor JD, et al. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid si Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1. Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Research. 2020, 30(1): 61-69. Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46. Liu Z, Nan Y, Luo Q, et al. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Research. 2022 Li J, Yu F, Guo H, et al. Crystal structure of plant PLD?1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D[J]. Cell Research. 2020, 30(1): 61-69.