TargetMol

PF-04457845

Product Code:
 
TAR-T4323
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4323-2mg2mg£95.00
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TAR-T4323-5mg5mg£109.00
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TAR-T4323-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T4323-10mg10mg£136.00
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TAR-T4323-25mg25mg£204.00
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TAR-T4323-50mg50mg£269.00
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TAR-T4323-100mg100mg£425.00
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TAR-T4323-200mg200mg£531.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2?0.63 nM) and rFAAH(IC50=7.4?0.62 nM).
CAS:
1020315-31-4
Formula:
C23H20F3N5O2
Molecular Weight:
455.441
Pathway:
Metabolism; Autophagy; Neuroscience
Purity:
0.9987
SMILES:
FC(F)(F)c1ccc(Oc2cccc(C=C3CCN(CC3)C(=O)Nc3cccnn3)c2)nc1
Target:
FAAH; Autophagy

References

Buntyn RW, et al. Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats. Int J Toxicol. 2017 Sep/Oct;36(5):395-402. Ahn K, et al. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. Johnson DS, et al. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.