TargetMol

OSS_128167

Product Code:
 
TAR-T4328
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4328-1mg1mg£101.00
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TAR-T4328-2mg2mg£114.00
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TAR-T4328-1mL1 mL * 10 mM (in DMSO)£139.00
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TAR-T4328-5mg5mg£139.00
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TAR-T4328-10mg10mg£166.00
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TAR-T4328-25mg25mg£269.00
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TAR-T4328-50mg50mg£436.00
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TAR-T4328-100mg100mg£610.00
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TAR-T4328-500mg500mg£1,219.00
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Further Information

Bioactivity:
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
CAS:
887686-02-4
Formula:
C19H14N2O6
Molecular Weight:
366.329
Pathway:
Microbiology/Virology; Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9925
SMILES:
OC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
Target:
HBV; Sirtuin

References

Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804. Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50.