TargetMol

NPS-2143 hydrochloride

Product Code:
 
TAR-T4967
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4967-1mg1mg£101.00
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TAR-T4967-2mg2mg£114.00
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TAR-T4967-5mg5mg£138.00
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TAR-T4967-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T4967-10mg10mg£173.00
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TAR-T4967-25mg25mg£252.00
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TAR-T4967-50mg50mg£356.00
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TAR-T4967-100mg100mg£495.00
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This product comes from: United States.
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Further Information

Bioactivity:
NPS-2143 is a selective potent calcium ion-sensing receptor antagonist.
CAS:
324523-20-8
Formula:
C24H26Cl2N2O2
Molecular Weight:
445.38
Pathway:
GPCR/G Protein
Purity:
0.9938
SMILES:
Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
Target:
CaSR

References

Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153(3):1232-41. Epub 2011 Dec 30. Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52(21), 6599-6605. Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56(5):753-60. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111(4):469-81. Epub 2012 Jun 22. Huang Y, Breitwieser GE. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J Biol Chem. 2007 Mar 30;282(13):9517-25