TargetMol

H-151

Product Code:
 
TAR-T5674
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5674-5mg5mg£108.00
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Quantity:
TAR-T5674-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T5674-10mg10mg£128.00
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TAR-T5674-25mg25mg£189.00
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TAR-T5674-50mg50mg£308.00
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Quantity:
TAR-T5674-100mg100mg£434.00
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Quantity:
TAR-T5674-500mg500mg£863.00
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This product comes from: United States.
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Further Information

Bioactivity:
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
CAS:
941987-60-6
Formula:
C17H17N3O
Molecular Weight:
279.343
Pathway:
Immunology/Inflammation
Purity:
0.9952
SMILES:
CCc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1
Target:
STING

References

Qiao W, Hu C, Ma J, et al.Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+ T anti-tumor immunity.Cancer Letters.2023: 216370. Li J, Sun Y, Zhao X, et al.Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.Cell Death & Disease.2023, 14(4): 1-16. Haag S M , Gulen M F , Luc R , et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018. Chen Q, Tang L, Zhang Y, et al. STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-?B/HIF-1? pathway. Life Sciences. 2022: 120089. Song P, Yang W, Lou K F, et al. UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum. EMBO reports. 2022: e55099