TargetMol

CK-869

Product Code:
 
TAR-T5860
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5860-2mg2mg£98.00
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TAR-T5860-5mg5mg£115.00
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TAR-T5860-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T5860-10mg10mg£142.00
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TAR-T5860-25mg25mg£213.00
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TAR-T5860-50mg50mg£303.00
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Quantity:
TAR-T5860-100mg100mg£442.00
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Further Information

Bioactivity:
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
CAS:
388592-44-7
Formula:
C17H16BrNO3S
Molecular Weight:
394.28
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
COc1ccc(N2C(SCC2=O)c2cccc(Br)c2)c(OC)c1
Target:
Microtubule Associated

References

Yamagishi Y , Oya K , Matsuura A , et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo[J]. Biochemical and Biophysical Research Communications, 2018, 496(3):834-839. Yvonne B , Vasquez R J , Jonathan S , et al. Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly[J]. PLoS ONE, 2014, 9(6):e100943-. Hetrick B , Han M , Helgeson L , et al. Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change[J]. Chemistry & Biology, 2013, 20(5):701-712.