TargetMol

Turofexorate Isopropyl

Product Code:
 
TAR-T6053
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6053-2mg2mg£102.00
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TAR-T6053-5mg5mg£122.00
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TAR-T6053-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T6053-10mg10mg£142.00
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TAR-T6053-25mg25mg£213.00
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TAR-T6053-50mg50mg£302.00
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TAR-T6053-100mg100mg£436.00
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This product comes from: United States.
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Further Information

Bioactivity:
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
CAS:
629664-81-9
Formula:
C25H24F2N2O3
Molecular Weight:
438.475
Pathway:
Metabolism; Autophagy
Purity:
0.9975
SMILES:
CC(C)OC(=O)C1=CN(CC(C)(C)c2c1[nH]c1ccccc21)C(=O)c1ccc(F)c(F)c1
Target:
FXR; Autophagy

References

Tschuck J, Theilacker L, Rothenaigner I, et al.Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.Nature Communications.2023, 14(1): 6908. Hartman HB, et al. J Lipid Res, 2009, 50(6), 1090-1100. Zheng W, Lu Y, Tian S, et al. Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR[J]. Journal of Biological Chemistry. 2018 Aug 10;293(32):12535-12541. Flatt B, et al. J Med Chem, 2009, 52(4), 904-907. Zheng W, Lu Y, Tian S, et al. Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR. Journal of Biological Chemistry. 2018 Aug 10;293(32):12535-12541 Zhang S, et al. Biochem Biophys Res Commun, 2009, 379(2), 476-479. Zhang S, et al. J Hepatol, 2009, 51(2), 380-388.