TargetMol

Brefeldin A

Product Code:
 
TAR-T6062
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6062-2mg2mg£98.00
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TAR-T6062-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6062-5mg5mg£109.00
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TAR-T6062-10mg10mg£117.00
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TAR-T6062-50mg50mg£230.00
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TAR-T6062-100mg100mg£360.00
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Further Information

Bioactivity:
Brefeldin A , a Penicillium brefeldianum metabolite, which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is also an ATPase inhibitor for protein transport in HCT 116 cells(IC50=0.2 μM), inducing Y cell differentiation and apoptosis.
CAS:
20350-15-6
Formula:
C16H24O4
Molecular Weight:
280.364
Pathway:
Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
Purity:
0.992
SMILES:
[H][C@@]12C[C@H](O)C[C@@]1([H])[C@H](O)C=CC(=O)O[C@@H](C)CCCC=C2
Target:
ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9

References

Wlodkowic D, et al. Leuk Res. 2007, 31(12), 1687-1700. Ma X, Zou F, Yu F, et al. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses[J]. Immunity. 2020 Zhang Y, Hu H, Liu W, et al. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity[J]. Journal for ImmunoTherapy of Cancer. 2021, 9(4): e002137. Bai R, Li L, Liu M, et al. Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical chemistry. 2018, 90(9): 5825-5832. Bai R, Li L, Liu M, et al. Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis[J]. Analytical chemistry. 2018, 90(9): 5825-5832. Franco M, et al. J Biol Chem. 1996, 271(3), 1573-1578. Hullin-Matsuda F, et al. J Biol Chem. 2012. Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. Yu T, Ling Q, Xu M, et al. ORF8 protein of SARS?CoV?2 reduces male fertility in mice. Journal of Medical Virology. 2022 Luo Q, Liu Q, Cheng H, et al. Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses. Cell reports. 2022, 40(7): 111195. Zhu JW, et al. Bioorg Med Chem. 2000, 8(2), 455-463. Ma X, Zou F, Yu F, et al. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9. Ohnishi Y, et al. Br J Pharmacol. 2001, 134(1), 168-178. Zhang X, Wu S, Liu J, et al.A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross?Protection Activity against Multiple SARS?CoV?2 Sublineages.Advanced Science.2023: 2301034.