TargetMol

ON-01910

Product Code:
 
TAR-T6070
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6070-1mg1mg£95.00
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TAR-T6070-2mg2mg£103.00
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TAR-T6070-5mg5mg£125.00
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TAR-T6070-10mg10mg£166.00
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TAR-T6070-1mL1 mL * 10 mM (in DMSO)£179.00
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TAR-T6070-25mg25mg£269.00
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TAR-T6070-50mg50mg£431.00
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TAR-T6070-100mg100mg£600.00
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Further Information

Bioactivity:
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
CAS:
1225497-78-8
Formula:
C21H24NNaO8S
Molecular Weight:
473.47
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9982
SMILES:
[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Target:
PLK

References

Dai, Yi-Han, Lai, et al. ON 01910.Na inhibits growth of diffuse large B-cell lymphoma by cytoplasmic sequestration of sumoylated C-MYB/TRAF6 complex[J]. Translational Research the Journal of Laboratory & Clinical Medicine, 2016. Gumireddy K , Reddy M V R , Cosenza S C , et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.[J]. Cancer Cell, 2005, 7(3):275-286.