TargetMol

Epothilone B

Product Code:
 
TAR-T6075
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6075-1mg1mg£95.00
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TAR-T6075-2mg2mg£105.00
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TAR-T6075-5mg5mg£119.00
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TAR-T6075-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T6075-10mg10mg£152.00
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TAR-T6075-25mg25mg£252.00
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TAR-T6075-50mg50mg£399.00
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TAR-T6075-100mg100mg£549.00
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This product comes from: United States.
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Further Information

Bioactivity:
Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
CAS:
152044-54-7
Formula:
C27H41NO6S
Molecular Weight:
507.68
Pathway:
Apoptosis; Microbiology/Virology; Cytoskeletal Signaling
Purity:
0.9954
SMILES:
C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/c1csc(n1)C)/C)C
Target:
Apoptosis; Microtubule Associated; Antibiotic; Antifungal

References

Lin B, et al. Blood, 2005, 105(1), 350-357. Kamath K, et al. Cancer Res, 2003, 63(18), 6026-6031. Bollag DM, et al. Cancer Res, 1995, 55(11), 2325-2333. Regueiro-Ren A , et al. Org Lett, 2001, 3(17), 2693-2696. Shahabi S, et al. Gynecol Oncol, 2010, 119(2), 345-350.