TargetMol

Rabusertib

Product Code:
 
TAR-T6084
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6084-2mg2mg£104.00
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TAR-T6084-5mg5mg£124.00
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TAR-T6084-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T6084-10mg10mg£164.00
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TAR-T6084-25mg25mg£246.00
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TAR-T6084-50mg50mg£364.00
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TAR-T6084-100mg100mg£538.00
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TAR-T6084-200mg200mg£599.00
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Quantity:
TAR-T6084-500mg500mg£870.00
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Further Information

Bioactivity:
Rabusertib is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non-Small Cell Lung Cancer.
CAS:
911222-45-2
Formula:
C18H22BrN5O3
Molecular Weight:
436.31
Pathway:
PI3K/Akt/mTOR signaling; Autophagy; Cell Cycle/Checkpoint
Purity:
0.9963
SMILES:
Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1
Target:
Chk; PDK; Autophagy

References

King C, et al. Invest New Drugs. 2014, 32(2):213-26. Govindan R. J Thorac Oncol, 2011, 6(11 Suppl 4), S1757. Emiliano Calvo1, et al. Mol Cancer Ther, 2011, A94. Zhang L, Wirth M, Patra U, et al.Actionable loss of SLF2 drives B?cell lymphomagenesis and impairs the DNA damage response.EMBO Molecular Medicine.2023: e16431.