TargetMol

Siponimod

Product Code:
 
TAR-T6403
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6403-2mg2mg£97.00
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TAR-T6403-5mg5mg£112.00
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TAR-T6403-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T6403-10mg10mg£134.00
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TAR-T6403-25mg25mg£185.00
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TAR-T6403-50mg50mg£259.00
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TAR-T6403-100mg100mg£333.00
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This product comes from: United States.
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Further Information

Bioactivity:
BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibits >1000-fold over S1P2, S1P3 and S1P4 receptors.
CAS:
1230487-00-9
Formula:
C29H35F3N2O3
Molecular Weight:
516.605
Pathway:
GPCR/G Protein
Purity:
0.9929
SMILES:
CCc1cc(ccc1CN1CC(C1)C(O)=O)C(C)=NOCc1ccc(C2CCCCC2)c(c1)C(F)(F)F
Target:
S1P Receptor; LPL Receptor

References

Lewis ND, et al. J Immunol, 2013, 190(7), 3533-3540. Fauzyah Y, Ono C, Torii S, et al. Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation. Antiviral Research. 2021 Feb;186:104999 Pan S, et al. ACS Med, Chem, Lett, 2013, 4 (3), 333?337. Gergely P, et al. Br J Pharmacol, 2012, 167(5), 1035-1047. Fauzyah Y, Ono C, Torii S, et al. Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation[J]. Antiviral Research. 2020: 104999.