TargetMol

Clevudine

Product Code:
 
TAR-T6446
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6446-2mg2mg£97.00
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TAR-T6446-5mg5mg£111.00
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TAR-T6446-10mg10mg£128.00
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TAR-T6446-1mL1 mL * 10 mM (in DMSO)£135.00
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TAR-T6446-25mg25mg£173.00
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TAR-T6446-50mg50mg£237.00
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Quantity:
TAR-T6446-100mg100mg£367.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
CAS:
163252-36-6
Formula:
C10H13FN2O5
Molecular Weight:
260.22
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Microbiology/Virology
Purity:
0.9998
SMILES:
Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O
Target:
HBV; DNA/RNA Synthesis

References

Korba BE, et al. Expert Rev Anti Infect Ther, 2006, 4(4), 549-561. Jacquard AC, et al. Antimicrob Agents Chemother, 2004, 48(7), 2683-2692. Chong Y, et al. Bioorg Med Chem Lett, 2002, 12(23), 3459-3462. Hu R, et al. Antimicrob Agents Chemother, 2005, 49(5), 2044-2049.