TargetMol

GDC-0349

Product Code:
 
TAR-T6510
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6510-1mg1mg£103.00
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TAR-T6510-2mg2mg£115.00
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TAR-T6510-5mg5mg£152.00
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TAR-T6510-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T6510-10mg10mg£217.00
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TAR-T6510-25mg25mg£374.00
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TAR-T6510-50mg50mg£526.00
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TAR-T6510-100mg100mg£724.00
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TAR-T6510-500mg500mg£1,420.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.
CAS:
1207360-89-1
Formula:
C24H32N6O3
Molecular Weight:
452.559
Pathway:
PI3K/Akt/mTOR signaling; Autophagy
Purity:
0.96
SMILES:
CCNC(=O)Nc1ccc(cc1)-c1nc2CN(CCc2c(n1)N1CCOC[C@@H]1C)C1COC1
Target:
PI3K; mTOR; Autophagy

References

Wang Z, Feng J, Yu J, et al. FKBP12 mediates necroptosis by initiating RIPK1?RIPK3?MLKL signal transduction in response to TNF receptor 1 ligation[J]. Journal of cell science. 2019 May 20;132(10). pii: jcs227777. Zhonghua Pei, et al. J Med Chem, 2013, 56(7), 3090-3101. Wang Z, Feng J, Yu J, et al. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Journal of Cell Science. 2019, 132(10): jcs227777