TargetMol

IOX1

Product Code:
 
TAR-T6545
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6545-2mg2mg£101.00
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TAR-T6545-5mg5mg£119.00
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TAR-T6545-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T6545-10mg10mg£143.00
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TAR-T6545-25mg25mg£230.00
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TAR-T6545-50mg50mg£334.00
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TAR-T6545-100mg100mg£462.00
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Further Information

Bioactivity:
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively.
CAS:
5852-78-8
Formula:
C10H7NO3
Molecular Weight:
189.17
Pathway:
Chromatin/Epigenetic
Purity:
0.9938
SMILES:
OC(=O)c1ccc(O)c2ncccc12
Target:
Histone Demethylase

References

Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019, 35(4): 677-691. e10. Schiller R, et al. ChemMedChem. 2014, 9(3), 566-571. Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia[J]. Cancer Cell. 2019, 35(4): 677-691. e10.