TargetMol

AMG-47a

Product Code:
 
TAR-T7123
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7123-1mg1mg£101.00
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TAR-T7123-5mg5mg£142.00
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TAR-T7123-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T7123-10mg10mg£195.00
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TAR-T7123-25mg25mg£281.00
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TAR-T7123-50mg50mg£383.00
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Quantity:
TAR-T7123-100mg100mg£531.00
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Further Information

Bioactivity:
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
CAS:
882663-88-9
Formula:
C29H28F3N5O2
Molecular Weight:
535.571
Pathway:
JAK/STAT signaling; Angiogenesis; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Stem Cells; MAPK
Purity:
0.98
SMILES:
Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Target:
VEGFR; p38 MAPK; JAK; Src

References

Carver J , Dexheimer T S , Hsu D , et al. A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein[J]. Plos One, 2014, 9(8):e103836.