TargetMol

JH-II-127

Product Code:
 
TAR-T7155
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7155-1mg1mg£116.00
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TAR-T7155-2mg2mg£136.00
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TAR-T7155-5mg5mg£177.00
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TAR-T7155-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T7155-10mg10mg£235.00
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TAR-T7155-25mg25mg£367.00
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TAR-T7155-50mg50mg£511.00
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TAR-T7155-100mg100mg£703.00
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Further Information

Bioactivity:
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),
CAS:
1700693-08-8
Formula:
C19H21ClN6O3
Molecular Weight:
416.87
Pathway:
Autophagy
Purity:
0.98
SMILES:
CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12
Target:
LRRK2

References

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6(5):584-589.