TargetMol

THZ2

Product Code:
 
TAR-T7296
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7296-1mg1mg£145.00
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TAR-T7296-5mg5mg£229.00
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TAR-T7296-1mL1 mL * 10 mM (in DMSO)£270.00
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TAR-T7296-10mg10mg£289.00
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TAR-T7296-25mg25mg£466.00
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TAR-T7296-50mg50mg£648.00
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TAR-T7296-100mg100mg£863.00
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Further Information

Bioactivity:
THZ2, an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).
CAS:
1604810-84-5
Formula:
C31H28ClN7O2
Molecular Weight:
566.06
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CN(C)CC=CC(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1
Target:
CDK

References

Jiang L, Yu Y, Li Z, et al.BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1.Viruses.2023, 15(8): 1642. Huang JR, Qin WM, Wang K,et al.Cyclin-dependent kinase 7 inhibitor THZ2 inhibits the growth of human gastric cancer in vitro and in vivo.Am J Transl Res. 2018 Nov 15;10(11):3664-3676. CDK7-dependent transcriptional addiction in triple-negative breast cancer.