TargetMol

Paquinimod

Product Code:
 
TAR-T7310
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7310-5mg5mg£132.00
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Quantity:
TAR-T7310-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T7310-10mg10mg£170.00
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TAR-T7310-25mg25mg£254.00
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TAR-T7310-50mg50mg£371.00
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TAR-T7310-100mg100mg£451.00
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Quantity:
TAR-T7310-500mg500mg£1,187.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Paquinimod is a S100A9 inhibitor preventing S100A9 binding to TLR-4.
CAS:
248282-01-1
Formula:
C21H22N2O3
Molecular Weight:
350.418
Purity:
0.9979
SMILES:
CCN(C(=O)c1c(O)c2c(CC)cccc2n(C)c1=O)c1ccccc1

References

Guo Q, Zhao Y, Li J, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19[J]. Cell Host & Microbe . 2020 Guo Q, Zhao Y, Li J, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host & Microbe. 2020 Schelbergen R F , Geven E J , Van d B M H J , et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis[J]. Annals of the Rheumatic Diseases, 2015:annrheumdis-2014-206517. StenstrM M , Nyhl?n, Hel?n Carlsson, T?Rngren M , et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis[J]. Journal of Dermatological Science, 2016:S0923181116300615.