TargetMol

GSK5182

Product Code:
 
TAR-T8370
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8370-1mg1mg£109.00
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TAR-T8370-2mg2mg£125.00
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TAR-T8370-5mg5mg£148.00
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TAR-T8370-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T8370-10mg10mg£195.00
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TAR-T8370-25mg25mg£303.00
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TAR-T8370-50mg50mg£422.00
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TAR-T8370-100mg100mg£590.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
CAS:
877387-37-6
Formula:
C27H31NO3
Molecular Weight:
417.549
Pathway:
Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κb
Purity:
0.9763
SMILES:
CN(C)CCOc1ccc(cc1)C(=C(CCCO)c1ccccc1)c1ccc(O)cc1
Target:
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Reactive Oxygen Species

References

Kim DK, et al. Inverse agonist of nuclear receptor ERR? mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes. 2013 Sep;62(9):3093-102. Kim JH, et al. Estrogen-related receptor ? is upregulated in liver cancer and its inhibition suppresses livercancer cell proliferation via induction of p21 and p27. Exp Mol Med. 2016 Mar 4;48:e213.