TargetMol

SC-43

Product Code:
 
TAR-T8478
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8478-1mg1mg£148.00
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TAR-T8478-5mg5mg£229.00
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TAR-T8478-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T8478-10mg10mg£303.00
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TAR-T8478-25mg25mg£502.00
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TAR-T8478-50mg50mg£687.00
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TAR-T8478-100mg100mg£863.00
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Further Information

Bioactivity:
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.
CAS:
1400989-25-4
Formula:
C21H13ClF3N3O2
Molecular Weight:
431.8
Pathway:
Metabolism; JAK/STAT signaling; Apoptosis; Stem Cells
Purity:
0.9926
SMILES:
FC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3ccc(cc3)C#N)c2)ccc1Cl
Target:
Apoptosis; Phosphatase; STAT

References

Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089. Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.