TargetMol

CPI-1205

Product Code:
 
TAR-T8510
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8510-1mg1mg£139.00
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TAR-T8510-2mg2mg£169.00
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TAR-T8510-5mg5mg£250.00
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TAR-T8510-10mg10mg£334.00
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TAR-T8510-25mg25mg£517.00
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TAR-T8510-1mL1 mL * 10 mM (in DMSO)£540.00
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TAR-T8510-50mg50mg£699.00
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This product comes from: United States.
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Further Information

Bioactivity:
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
CAS:
1621862-70-1
Formula:
C27H33F3N4O3
Molecular Weight:
518.581
Pathway:
Chromatin/Epigenetic
Purity:
0.997
SMILES:
COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12
Target:
Histone Methyltransferase

References

Vaswani RG, et al. Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J Med Chem. 2016 Nov 10;59(21):9928-9941. Gulati N , B?guelin, Wendy, Giulino-Roth L . Enhancer of zeste homolog 2 (EZH2) inhibitors[J]. Leukemia & Lymphoma, 2018:1-12.