TargetMol

BMS-345541 hydrochloride

Product Code:
 
TAR-T8542
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8542-1mg1mg£98.00
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TAR-T8542-2mg2mg£109.00
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TAR-T8542-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T8542-5mg5mg£134.00
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TAR-T8542-10mg10mg£173.00
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TAR-T8542-25mg25mg£260.00
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TAR-T8542-50mg50mg£389.00
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TAR-T8542-100mg100mg£547.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
CAS:
547757-23-3
Formula:
C14H18ClN5
Molecular Weight:
291.78
Pathway:
NF-κb
Purity:
0.9992
SMILES:
Cl.Cc1cnc2c(NCCN)nc3ccc(C)cc3n12
Target:
IκB/IKK

References

Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456. MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960.