TargetMol

VH-298

Product Code:
 
TAR-TQ0121
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0121-1mg1mg£102.00
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TAR-TQ0121-2mg2mg£115.00
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TAR-TQ0121-5mg5mg£161.00
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TAR-TQ0121-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-TQ0121-10mg10mg£229.00
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TAR-TQ0121-25mg25mg£367.00
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TAR-TQ0121-50mg50mg£528.00
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TAR-TQ0121-100mg100mg£728.00
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TAR-TQ0121-500mg500mg£1,428.00
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Further Information

Bioactivity:
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
CAS:
2097381-85-4
Formula:
C27H30N5O4S
Molecular Weight:
523.65
Pathway:
Angiogenesis|Chromatin/Epigenetic|Others|PROTAC
Purity:
1
SMILES:
CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)C=C1
Target:
Ligand for E3 Ligase|HIF|Others

References

Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-? hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.