TargetMol

AMG8380

Product Code:
 
TAR-T10301
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10301-5mg5mg£850.00
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Further Information

Bioactivity:
AMG8380 is an orally active and less active enantiomer of AMG8379 served as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 (IC50s: 0.907 and 0.387 μM). AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels (IC50: 2560 nM).
CAS:
1642112-32-0
Formula:
C25H16ClF2N3O5S
Molecular Weight:
543.93
Purity:
0.98
SMILES:
O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]

References

1. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.