TargetMol

AMG8379

Product Code:
 
TAR-T10301L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10301L-5mg5mg£1,010.00
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TAR-T10301L-50mg50mg£1,982.00
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TAR-T10301L-100mg100mg£2,560.00
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Further Information

Bioactivity:
AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1]. AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7. With IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively.
CAS:
1642112-31-9
Formula:
C25H16ClF2N3O5S
Molecular Weight:
543.93
Purity:
0.98
SMILES:
COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1

References

1. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.