TargetMol

EGFR-IN-1 hydrochloride

Product Code:
 
TAR-T11157L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11157L-1mg1mg£209.00
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TAR-T11157L-5mg5mg£413.00
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TAR-T11157L-1mL1 mL * 10 mM (in DMSO)£545.00
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TAR-T11157L-10mg10mg£578.00
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TAR-T11157L-25mg25mg£863.00
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TAR-T11157L-50mg50mg£1,155.00
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TAR-T11157L-100mg100mg£1,540.00
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TAR-T11157L-500mg500mg£3,010.00
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This product comes from: United States.
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Further Information

Bioactivity:
EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 hydrochloride is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 hydrochloride potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR.
CAS:
2227455-78-7
Formula:
C28H31ClN6O4
Molecular Weight:
551.04
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.98
SMILES:
Cl.COc1cc(OCCN(C)C)ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1
Target:
EGFR

References

1. Wurz RP, et al. Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors. ACS Med Chem Lett. 2015 Jul 27;6(9):987-92.