TargetMol

Galidesivir triphosphate

Product Code:
 
TAR-T11352
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11352-5mg5mg£850.00
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Further Information

Bioactivity:
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.
CAS:
1467740-78-8
Formula:
C11H18N5O12P3
Molecular Weight:
505.209
Purity:
0.98
SMILES:
Nc1ncnc2c(c[nH]c12)[C@@H]1N[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

References

1. Evans GB, et al. Immucillins in Infectious Diseases. ACS Infect Dis. 2018 Feb 9;4(2):107-117. 2. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014 Apr 17;508(7496):402-5. 3. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016 May-Jun;9(3):220-6.