TargetMol

J30-8

Product Code:
 
TAR-T11702
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11702-100mg100mgEnquire
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Further Information

Bioactivity:
J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases. J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2.
CAS:
2366255-71-0
Formula:
C17H9ClFN3O2S
Molecular Weight:
373.79
Purity:
0.98
SMILES:
Fc1ccc2NC(=O)C(=C3/SC(NC3=O)=N/c3ccccc3Cl)c2c1

References

1. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.