TargetMol

MIV-247

Product Code:
 
TAR-T12051
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T12051-5mg5mg£1,251.00
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TAR-T12051-50mg50mg£2,464.00
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TAR-T12051-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
CAS:
1352817-76-5
Formula:
C17H24F3N3O4
Molecular Weight:
391.39
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
FC1(-;@C-;@C-;@C-;@C-;@1)C[C@H](NC(C(F)(F)C)=O)C(NC2(-;@C-;@C-;@C-;@2)C(C(N)=O)=O)=O
Target:
Cysteine Protease

References

1. Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.