TargetMol

(S)-Thalidomide

Product Code:
 
TAR-T12644L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
(S)-Thalidomide is the S-enantiomer of Thalidomide. (S)-Thalidomide causes teratogenic effects by binding to cereblon. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic, and proapoptotic effects.
CAS:
841-67-8
Formula:
C13H10N2O4
Molecular Weight:
258.233
Purity:
0.98
SMILES:
O=C1N([C@H]2CCC(=O)NC2=O)C(=O)c2ccccc12

References

1. Liu WM, et al. s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line. Hematol J. 2004;5(3):247-54. 2. Stephens TD. The effect of thalidomide in chicken embryos. Birth Defects Res A Clin Mol Teratol. 2009 Aug;85(8):725-31. 3. Murphy S, et al. Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. J Pharm Pharmacol. 2007 Jan;59(1):105-14. 4. Tokunaga E, et al. Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers. Sci Rep. 2018 Nov 20;8(1):17131.