TargetMol

Solabegron HCl

Product Code:
 
TAR-T12970L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12970L-5mg5mg£930.00
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TAR-T12970L-50mg50mg£1,821.00
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Quantity:
TAR-T12970L-100mg100mg£2,319.00
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Further Information

Bioactivity:
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells.
CAS:
451470-34-1
Formula:
C23H24Cl2N2O3
Molecular Weight:
447.36
Purity:
0.98
SMILES:
Cl.O[C@@H](CNCCNc1cccc(c1)-c1cccc(c1)C(O)=O)c1cccc(Cl)c1

References

1. Rosa GM, Ferrero S, Nitti VW, Wagg A, Saleem T, Chapple CR. Cardiovascular Safety of ?(3)-adrenoceptor Agonists for the Treatment of Patients with Overactive Bladder Syndrome. Eur Urol. 2015 Sep 28. pii: S0302-2838(15)00864-7. doi: 10.1016/j.eururo.2015.09.007. [Epub ahead of print] Review. PubMed PMID: 26422675. 2. Thiagamoorthy G, Giarenis I, Cardozo L. Early investigational ?3 adreno-receptor agonists for the management of the overactive bladder syndrome. Expert Opin Investig Drugs. 2015;24(10):1299-306. doi: 10.1517/13543784.2015.1076390. Epub 2015 Aug 14. PubMed PMID: 26292923. 3. Hertzberg R, Monreal Santiago G, Moberg C. Synthesis of the ?3-adrenergic receptor agonist solabegron and analogous N-(2-ethylamino)-?-amino alcohols from O-acylated cyanohydrins - expanding the scope of minor enantiomer recycling. J Org Chem. 2015 Mar 6;80(5):2937-41. doi: 10.1021/acs.joc.5b00322. Epub 2015 Feb 24. PubMed PMID: 25689345. 4. Ellsworth P, Fantasia J. Solabegron: a potential future addition to the ?-3 adrenoceptor agonist armamentarium for the management of overactive bladder. Expert Opin Investig Drugs. 2015 Mar;24(3):413-9. doi: 10.1517/13543784.2015.1001836. Epub 2015 Jan 5. Review. PubMed PMID: 25557359.