TargetMol

Succinyl phosphonate trisodium salt

Product Code:
 
TAR-T13019
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13019-1mg1mg£181.00
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TAR-T13019-2mg2mg£230.00
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TAR-T13019-5mg5mg£346.00
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TAR-T13019-10mg10mg£464.00
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TAR-T13019-25mg25mg£699.00
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TAR-T13019-50mg50mg£946.00
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Quantity:
TAR-T13019-100mg100mg£1,259.00
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Further Information

Bioactivity:
Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
CAS:
864167-45-3
Formula:
C4H4Na3O6P
Molecular Weight:
248.013
Pathway:
NF-κb; Metabolism; Immunology/Inflammation
Purity:
0.98
SMILES:
[Na]OC(=O)CCC(=O)P(=O)(O[Na])O[Na]
Target:
Dehydrogenase; Reactive Oxygen Species; Endogenous Metabolite

References

1. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. 2. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21. 3. Z?ndorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. 4. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.