TargetMol

UT-34

Product Code:
 
TAR-T13273
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13273-1mg1mg£109.00
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TAR-T13273-2mg2mg£130.00
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TAR-T13273-5mg5mg£168.00
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TAR-T13273-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T13273-10mg10mg£228.00
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TAR-T13273-25mg25mg£436.00
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TAR-T13273-50mg50mg£608.00
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TAR-T13273-100mg100mg£836.00
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Further Information

Bioactivity:
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prostate cancer efficacy.
CAS:
2168525-92-4
Formula:
C15H12F4N4O2
Molecular Weight:
356.281
Pathway:
Endocrinology/Hormones
Purity:
0.981
SMILES:
C[C@](O)(Cn1cc(F)cn1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
Target:
Androgen Receptor

References

1. Ponnusamy S, et al. Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer. Clin Cancer Res. 2019 Nov 15;25(22):6764-6780. 2. Stone L. UT-34: a promising new AR degrader. Nat Rev Urol. 2019 Nov;16(11):640.